3 (nu-sodium formaldehyde sulphoxylate) amino-4-hydroxy-phenyl-arsonic acid



Patented Mar. 23, 1937 UNITED STATES PATENT OFFICE 8(N-SODIUM FORMALDEHYDE SULPHOXY- LATE) AMINO-*l-HYDROXY-PHENYL AR SONIC ACID Illinois No Drawing. Application November 18, 1935, Serial No. 50,364

3 Claims.

Our invention relates to a derivative of aminohydroxyl phenyl arsonic acid which has been found to possess remarkable therapeutic properties, particularly in the treatment of such 5 diseases as Trichomonas vaginitz'a. It has also therapeutic efiects in amoebic dysentery and syphilis.

Our improved compound is formed by the combination of amino-hydroxy phenyl arsonic acid and sodium formaldehyde sulphoxylate. Aside from its therapeutic efliciency, the product is of considerable advantage in that it is quite stable for substantial periods of time, is water soluble, and is neutral or slightly alkaline.

The following is an example of a method whereby the material may be prepared:

E wample At the present time we are unable to state definitely the nature of the reaction outlined above or the structure of the product formed thereby, except to say that, in the resulting product, the arsenic retains its pentavalent con- 5 dition.

It should be understood that we do not consider ourselves limited to the specific details set forth above but intend that the scope of our invention should be determined from the following 1Q claims, which should be interpreted as broadly as the state of the art will permit.

We claim as our invention:

1. A composition of matter formed by the interaction of a minor proportion of sodium formal- 15 dehyde sulphoxylate with a major proportion of amino-hydroxy phenyl arsonic acid, the arsenic atom of said composition being pentavalent.

2. A composition of matter formed by the in teraction of a minor proportion of sodium for- 20 maldehyde sulphoxylate with a major proportion of 3-amino-4-hydroxy phenyl arsonic acid, the arsenic atom of said composition being pentavalent.

3. A composition of matter having the arsenic atom in pentavalent form consisting of the reaction product of about 1 part of sodium formaldehyde sulphoxylate and about 2 parts of 3- amino-4-hydroxy-phenyl-arsonic acid.

GEORGE W. RAIZISS. ABRAHAM I. KREMENS. 

